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Journal of Forensic Medicine ; (6): 223-225, 2005.
Article in Chinese | WPRIM | ID: wpr-983113

ABSTRACT

Cyclooxygenase (COX) is the obligate, rate-limiting enzyme for the conversion of arachidonic acid into prostaglandins, which mediate mitogenesis, apoptosis, angiogenesis, blood flow, secondary injury, and inflammation. COX is consist of 2 subtypes: COX-1 and COX-2. In recent years, there are a number of lines of evidence that COX-1 and COX-2 play a important in role brain injuries.


Subject(s)
Animals , Humans , Rats , Apoptosis/drug effects , Brain Injuries/pathology , Cyclooxygenase 1/metabolism , Cyclooxygenase 2/metabolism , Cyclooxygenase Inhibitors/therapeutic use , Immunohistochemistry , Neurons/drug effects , Time Factors
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